R&D SERVICES

Craif has created a powerful platform to unveil cellular communications by exosomal enrichment. We are a custom solutions provider offering unique expertise and services that help solve complex clinical questions on behalf of our partners.

NANOWIRE DEVICE PAVED THE WAY FOR EXOSOME RESEARCH

Our device captures urinal exosomes by electric interaction with nanowires in a microfluid. By using our technology, we can extract and measure urinal miRNAs and their expression patterns comprehensively. While conventional methods (e.g., ultracentrifugation) can capture only 15-20% of urinary exosomes despite hours of preparation, our ZnO nanowire device can collect more than 99% of the exosomes in 40 minutes.

APPLICATIONS

Understanding the cellular communication enable various applications

  • CLINICAL DIAGNOSTICS

    High-throughput (HTS) and high-content screening (HCS) of exosomal biomarkers to identify predictive biomarkers, patient stratification, and MRD detection

  • DRUG DISCOVERY

    HTS and HCS of biofluids from patients to elucidate disease mechanisms and potential targets

  • CELL THERAPY RESEARCH

    HTS and HTC of cell culture supernatants to identify key MoA of cell therapies and metrics for quality control

OUR SERVICES

End to end research services provided
by interdisciplinary team of experts


  • BIOMARKER
    DISCOVERY

    Rapidly identifying more than a thousand biomarkers from a single urine draw

  • LARGE-SCALE
    DATA ANALYSIS

    Harnessing machine learning to develop classifier of disease/non-disease

  • BIOINFORMATICS

    Identifying key biomarkers and revealing physiological insights

CASE STUDY

Identifying NASH-specific microRNA profiles by analyzing urine


Our technology platform can be applied not only to cancer but also non-cancer diseases


PARTNERS

Major Japanese pharmaceutical company(Undisclosed)
Major Japanese manufacturer(Undisclosed)